October 2006, New
GeneMarker® module for MLPA Analysis Using
Luminex xMap® Technology
BioGene announce the introduction of a new module in GeneMarker®
software for MLPA analysis utilising Luminex xMap technology,
which was developed in collaboration with Dr. Brian Dawson,
of the Mayo Clinic and Foundation.
MLPA has proven to be an important technique in the detection
of exon copy number changes associated with breast and colon
cancers, as well as trisomies found in Down Syndrome (3,
4, 5). Coupling MLPA with Luminex microsphere technology
has the potential to also be as important in the detection
of copy number changes associated with Niemann-Pick type
C (6, 7, 8), alpha-thalassemia (8) and other genetic diseases.
Accurate analysis of Luminex-microsphere flow cytometry
instrument generated data is critical to disease diagnosis.
GeneMarker® now includes a Luminex-MLPA
module that quickly and accurately analyses data from Luminex
instruments (Luminex 100 and Luminex 200). The software
is compatible with the Luminex instrument data format (*.csv).
GeneMarker® Luminex-MLPA analysis automatically
performs background subtraction, and flags suspect intensities
according to user-specified thresholds. The software selects
the least variable sample, from the sample set to act as
the reference for determining copy number change within
the patient sample set. For further information or a trial
of the software please visit contact us.